Germline deletion of Krüppel-like factor 14 does not increase risk of diet-induced metabolic syndrome in male C57BL/6 mice

The transcription factor Krüppel-like factor 14 (KLF14) has been associated with type 2 diabetes and high-density lipoprotein-cholesterol (HDL-C) through genome-wide association studies. The mechanistic underpinnings of KLF14's control of metabolic processes remain largely unknown. We studied the physiological roles of KLF14 in a knockout (KO) mouse model. 10 samples from pituitary (5 WT and 5 KLF14 KO) and 10 samples from inguinal white adipose tissue (5 WT and 5 KLF14 KO) were analyzed

转录因子Krüppel样因子14（Krüppel-like factor 14, KLF14）已通过全基因组关联研究被证实与2型糖尿病及高密度脂蛋白胆固醇（high-density lipoprotein-cholesterol, HDL-C）存在关联。目前，KLF14调控代谢过程的分子机制仍未完全阐明。本研究借助基因敲除（knockout, KO）小鼠模型，探究了KLF14的生理功能。研究共分析了20份样本：10份取自垂体组织（5份野生型（wild type, WT）与5份KLF14基因敲除型），剩余10份取自腹股沟白色脂肪组织（5份WT与5份KLF14基因敲除型）