Cutaneous ganglion cell choristoma. Report of a case

We describe the histological, immunohistochemical, and ultrastructural findings of a cutaneous tumour composed of ganglion cells, without any other proliferating component. As ganglion cells are not normal components of the skin, we propose the term “ganglion cell choristoma” for this lesion. The differential diagnosis of related lesions such as cutaneous ganglioneuroma, well-differentiated metastases from neuroblastoma, autonomic ganglia entrapped by neuroflbroma, and reactive processes, and the possible histogenesis of ganglion cell choristoma are discussed.本研究描述了一种由神经节细胞构成、无其他增殖性成分的皮肤肿瘤的组织学、免疫组织化学及超微结构特征。鉴于神经节细胞并非皮肤的正常组成成分，我们将该病变命名为“神经节细胞迷芽瘤（ganglion cell choristoma）”。本文还讨论了该病变的鉴别诊断范围，涵盖皮肤神经节神经瘤、神经母细胞瘤来源的高分化转移瘤、被神经纤维瘤嵌留的自主神经节以及反应性病变等相关病变，并探讨了神经节细胞迷芽瘤可能的组织发生机制。