Supporting data for 'Immunomodulation by Systemic Administration of Exosome Derived from Induced Pluripotent Stem Cell Mesenchymal Stem Cells to AlleviateLiver Inflammation and FibrosisinWilson’s disease'

Exosomes derived from mesenchymal stem cells (MSCs) are proposed to have anti-inflammatory and immunomodulation effects. We sought to determine the therapeutic effects of human induced pluripotent stem cell (hiPSC)-MSC derived exosomes to alleviate liver inflammation and fibrosis in Wilson’s disease (WD).
Our findings demonstrated that hiPSC-MSC-Ex could ameliorate hepatic fibrosis in the WD mouse model via immunomodulation and macrophage polarization. These results support the development of hiPSC-MSC-Ex as a cell-free therapy for WD as well as other chronic liver diseases.

间充质干细胞（mesenchymal stem cells, MSCs）来源的外泌体被认为具备抗炎与免疫调节的生物学功效。本研究旨在探究人诱导多能干细胞（human induced pluripotent stem cell, hiPSC）-MSC衍生外泌体对威尔逊病（Wilson’s disease, WD）小鼠肝脏炎症及纤维化的治疗作用。
研究结果显示，hiPSC-MSC-Ex可通过免疫调节与巨噬细胞极化改善威尔逊病小鼠模型的肝纤维化。上述结果支持将hiPSC-MSC-Ex作为威尔逊病及其他慢性肝病的无细胞治疗方案。