遇见数据集

Highly differentiated SNPs where Wewak C580Y mutants and Papua Indonesia parasites carry the same allele.

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Figshare2020-12-15 更新2026-04-28 收录
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Each row shows a non-synonymous SNP that is highly differentiated between the Wewak (PNG) and Timika (Indonesia) populations (FST ≥ 0.3) at which the Wewak C580Y mutants carry the allele that is most prevalent in Timika. The columns show: the chromosome number and nucleotide position of the SNP; the name and ID of the gene containing the SNP (genes associated with drug resistance are shown on a coloured background); the mutation name, showing amino acid change and position; the frequency of the mutant allele, in Wewak and in Timika (background colour intensity is proportional to the value); the FST between the two populations; the proportion of sample pairs that are in IBD with Wewak C580 samples at that position, in Wewak and Timika (background colour intensity is proportional to the value); and the Pubmed PMID reference of literature that implicates the gene in drug resistance, if applicable. (XLSX)

本数据集每一行对应一个非同义单核苷酸多态性(Single Nucleotide Polymorphism, SNP)位点:此类位点在韦瓦克(巴布亚新几内亚,PNG)与蒂米卡(印度尼西亚)两个群体间呈现高度分化(群体固定指数FST ≥ 0.3),且韦瓦克群体的C580Y突变株所携带的等位基因,正是蒂米卡群体中最常见的等位基因。各列信息如下:该SNP所在的染色体编号与核苷酸位点;包含该SNP的基因名称及基因ID(与耐药性相关的基因将以彩色背景高亮显示);突变名称,标注了氨基酸变化与对应位点;韦瓦克与蒂米卡群体中突变等位基因的频率(背景色强度与该频率数值成正比);两个群体间的FST值;韦瓦克与蒂米卡群体中,在该位点与韦瓦克C580样本存在同源片段相同(Identity By Descent, IBD)的样本对占比(背景色强度与该占比数值成正比);以及若存在相关文献,标注将该基因与耐药性相关联的PubMed文献编号(PubMed Identification Number, PMID)。本数据集格式为XLSX。

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2020-12-15
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