NET-ex Evaluation of MRI of the liver in the diagnostic accuracy of extrahepatic metastases

Interventions: Group 1: Cohort study: retrospective, non-randomized, monocentric, single-arm study.
This study is a retrospective cohort analysis. We evaluate data from patients with neuroendocrine tumors who underwent liver MRI with liver-specific contrast agent and 68Ga-DOTATATE (-TOC, NOC) PET/CT at a maximum interval of 3 months at the Institute of Clinical Radiology/ Clinic and Polyclinic of Radiology and the Clinic of Nuclear Medicine of the University Hospital of Munich during the period 2010-2021. The MRI sequences will be evaluated in 3 different sessions and compared and analyzed with the gold standard, PET/CT.
Primary outcome(s): Sensitivity, specificity, negative and positive predictive value of liver MRI (for different sequences) for extrahepatic metastases.
Study Design: Allocation: ; Masking: ; Control: ; Assignment: ; Study design purpose: diagnostic

干预措施：第1组：队列研究：回顾性、非随机、单中心、单臂研究。
本研究为回顾性队列分析，纳入2010年至2021年期间，慕尼黑大学医院临床放射学研究所、放射科及放射门诊与核医学科收治的、接受肝脏特异性对比剂肝脏磁共振成像（Magnetic Resonance Imaging, MRI）与68Ga-DOTATATE（-TOC、NOC）正电子发射计算机断层显像（Positron Emission Computed Tomography/Computed Tomography, PET/CT）检查，且两项检查间隔最长不超过3个月的神经内分泌肿瘤患者数据。研究将分3次独立阅片环节对MRI序列进行评估，并以PET/CT作为金标准开展对比分析。
主要结局指标：针对不同序列的肝脏MRI，其用于检测肝外转移灶的灵敏度、特异度、阴性预测值及阳性预测值。
研究设计：分组：无；设盲：无；对照：无；分配方式：无；研究设计目的：诊断性研究。