Oligonucleotide sequences.

Nanoplastics (NPs) have been found in many ecological environments (aquatic, terrestrial, air). Currently, there is great concern about the exposition and impact on animal health, including humans, because of the effects of ingestion and accumulation of these nanomaterials (NMs) in aquatic organisms and their incorporation into the food chain. NPs´ mechanisms of action on humans are currently unknown. In this study, we evaluated the altered molecular mechanisms on human neural stem cell line (hNS1) after 4 days of exposure to 30 nm polystyrene (PS) NPs (0.5, 2.5 and 10 μg/mL). Our results showed that NPs can induce oxidative stress, cellular stress, DNA damage, alterations in inflammatory response, and apoptosis, which could lead to tissue damage and neurodevelopmental diseases.

纳米塑料（Nanoplastics，NPs）已在多种生态环境（水生、陆生及大气环境）中被检出。目前，这类纳米材料（Nanomaterials，NMs）在水生生物体内的摄入与蓄积，以及其通过食物链的富集，已引发学界对其包括人类在内的动物健康的暴露效应与影响的广泛关注。当前，纳米塑料对人体的作用机制仍不明确。本研究以人神经干细胞系（hNS1）为模型，评估了暴露于30纳米聚苯乙烯（Polystyrene，PS）纳米塑料（浓度分别为0.5、2.5和10 μg/mL）4天后，该细胞系的分子机制异常变化。研究结果显示，纳米塑料可诱导氧化应激、细胞应激、DNA损伤、炎症反应紊乱及细胞凋亡，上述效应可能引发组织损伤与神经发育类疾病。