ROCK1 inhibition reduces steroid-refractory acute graft-versus-host disease

To identify kinases in immune cells of patients with SR-GVHD we isolated leukocytes and specifically enriched kinases via kinet-beads-technology. Rho Kinase Type 1 (ROCK1) was identified as the most abundant kinase in SR-GVHD.

为鉴定类固醇难治性移植物抗宿主病（SR-GVHD）患者免疫细胞内的激酶，我们分离了白细胞，并通过激酶磁珠技术（kinet-beads-technology）实现了激酶的特异性富集。1型Rho激酶（Rho Kinase Type 1，ROCK1）被鉴定为SR-GVHD中丰度最高的激酶。