Dataset: effect estimates obtained from randomised and non-randomised studies

This dataset provides study-level information on matched sets of published randomised and non-randomised studies answering the same clinical questions. The dataset includes 346 meta-analyses, and data on over 2,700 unique studies. The dataset includes the following information (definitions and coding are provided in the spreadsheet): IDs for clinical topics and source meta-analyses IDs for individual studies Brief descriptions of clinical topics Therapeutic area (ATC Code first level) Topic narrowness categorical Indicators for high-quality source meta-analyses (Cochrane review; top journal) Time period Comparator type Outcome type Meta-analysis-level median risk of bias for NRS and RCT Publication year of individual studies Risk of Bias in individual studies Standardised effect estimates (logOR) and variance for each study Summary logOR and variance for NRS and RCT, respectively, within each meta-analysis for the full sample The protocol for this study was registered on PROSPERO: Maximilian Salcher-Konrad. Comparison of treatment effects in randomised vs. non-randomised studies and the role of analytical methods to control for confounding: a meta-epidemiological study. PROSPERO 2018 CRD42018062204 Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42018062204本数据集提供针对同一临床问题的已发表随机对照试验与非随机研究匹配组的研究级信息。本数据集涵盖346项元分析，以及超过2700项独立研究的相关数据。 本数据集包含以下内容（定义与编码详见配套电子表格）： - 临床主题与源元分析的标识符 - 单个研究的标识符 - 临床主题简要描述 - 治疗领域（一级解剖治疗化学代码，ATC） - 主题细分程度分类变量 - 高质量源元分析标识指标（Cochrane系统综述；顶级期刊刊载） - 研究时间段 - 对照类型 - 结局类型 - 元分析层面的非随机研究（Non-Randomised Study, NRS）与随机对照试验（Randomised Controlled Trial, RCT）的偏倚风险中位数 - 单个研究的发表年份 - 单个研究的偏倚风险 - 各研究的标准化效应估计值（对数比值比（logOR））与方差 - 各元分析内全样本中，非随机研究与随机对照试验各自的汇总对数比值比及其方差 本研究的方案已在PROSPERO平台注册： 马克西米利安·扎尔-康拉德（Maximilian Salcher-Konrad）。随机对照试验与非随机研究的治疗效应比较及混杂控制分析方法的作用：一项元流行病学研究。PROSPERO 2018 CRD42018062204 可从以下网址获取：https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42018062204