HMGA1 induces FGF19 to drive pancreatic carcinogenesis and stroma formation

To investigate the effect of HMGA1 in pancreatic cancer. Here we established E3LZ10.7 cell lines in which HMGA1 has been knocked down by shRNA. We then performed gene expression profiling analysis using data obtained from RNA-seq Comparative gene expression profiling analysis of RNA-seq data for E3LZ10.7 cells with or without HMGA1 silencing

为探究高迁移率族蛋白A1（HMGA1）在胰腺癌中的作用，本研究构建了经短发夹RNA（shRNA）敲低HMGA1的E3LZ10.7细胞系。随后，我们针对HMGA1沉默与未沉默的E3LZ10.7细胞的RNA测序（RNA-seq）数据开展了比较基因表达谱分析。