Complete and de novo assembly of the Leishmania braziliensis (M2904) genome

Leishmania braziliensis is the etiological agent of American mucosal leishmaniasis, one of the most severe clinical forms of leishmaniasis. Here, we report the assembly of the L. braziliensis (M2904) genome into 35 continuous chromosomes. Also, the annotation of 8395 genes is provided. The public availability of this information will contribute to a better knowledge of this pathogen and help in the search for vaccines and novel drug targets aimed to control the disease caused by this Leishmania species.巴西利什曼原虫（Leishmania braziliensis）是美洲黏膜利什曼病的病原体，而美洲黏膜利什曼病是利什曼病中最为严重的临床分型之一。本研究完成了巴西利什曼原虫M2904菌株的基因组组装，将其基因组拼接为35条连续染色体，并完成了该基因组中8395个基因的注释工作。该研究相关数据的公开将有助于学界深化对该病原体的认知，同时为靶向该利什曼原虫所致疾病的疫苗研发与新型药物靶点筛选提供有力支撑。