Global gene transcription analysis in response to changes in chromosome supercoiling in Streptomyces coelicolor. Global gene transcription analysis in response to changes in chromosome supercoiling in Streptomyces coelicolor

We address the transcriptional response to both novobiocin-induced rapid chromosome relaxation or long-term topological imbalance, both increased and decreased supercoiling, in environmental antibiotic-producing bacteria belonging to the Streptomyces genus.

本研究针对隶属于链霉菌属（Streptomyces）的产抗生素环境细菌，探究其在新生霉素诱导的染色体快速松弛，以及兼具超螺旋升高与降低的长期拓扑失衡条件下的转录响应。