Multiple White and Flat Elevated Lesions Observed in the Stomach: A Prospective Study of Clinical Characteristics and Risk Factors.

This data was used for the following research.Intern Med. 2018 Apr 27. doi: 10.2169/internalmedicine.9889-17. [Epub ahead of print]Multiple White and Flat Elevated Lesions Observed in the Stomach: A Prospective Study of Clinical Characteristics and Risk Factors.Majima K, Muraki Y, Shimamoto T.AbstractObjective Multiple white and flat elevated lesions (MWFLs) observed in the stomach have only been presented in abstracts at academic conferences over the last decade; therefore, relatively little is known about these lesions. Our aim was to prospectively clarify the clinical characteristics of MWFLs, to identify their risk factors and to retrospectively evaluate the clinical progression of these lesions. Methods A prospective analysis of clinical characteristics and risk factors was conducted in participants who underwent esophagogastroduodenoscopic screening at our hospital. A retrospective analysis of the medical chart of patients identified as having MWFLs was conducted to describe the clinical progression of these lesions. Results The prevalence rate of MWFLs was 10.4% (80/767), with the following risk factors identified on a logistic regression analysis: use of proton pump inhibitors (odds ratio [OR], 3.51; 95% confidence interval [CI], 1.92-6.43), female sex (OR, 1.92; 95% CI, 1.19-3.12) and a 1-year increase in age (OR, 1.05; 95% CI, 1.02-1.08). Among the 70 cases with MWFLs observed over a mean duration of 2.3 years, no progression of MWFLs was detected in 67 cases (96%). Among the 3 remaining cases, progression was mild, with none of the lesions progressing to malignancy. Conclusion The use of PPIs, female sex, and age are risk factors for MWFLs. We believe that endoscopists should recognize these lesions.本数据集用于以下发表于《Internal Medicine》2018年4月27日的研究，DOI: 10.2169/internalmedicine.9889-17，[在线提前出版]。作者：Majima K、Muraki Y、Shimamoto T。 摘要 研究背景与目的：近十年来，胃内多发白色平坦隆起性病变（Multiple White and Flat Elevated Lesions, MWFLs）仅在学术会议的摘要中被报道，因此目前对这类病变的认知相对匮乏。本研究旨在前瞻性阐明MWFLs的临床特征，明确其相关危险因素，并回顾性评估这类病变的临床进展情况。 方法：本研究对在我院接受食管胃十二指肠镜筛查的受试者开展临床特征与危险因素的前瞻性分析；同时对确诊为MWFLs的患者的病历资料进行回顾性分析，以描述这类病变的临床进展。 结果：MWFLs的检出率为10.4%（80/767）。经logistic回归分析显示，质子泵抑制剂（proton pump inhibitors, PPIs）使用史（比值比[OR]=3.51，95%置信区间[CI]：1.92~6.43）、女性性别（OR=1.92，95%CI：1.19~3.12）以及年龄每增长1岁（OR=1.05，95%CI：1.02~1.08）为MWFLs的独立危险因素。在平均随访时长2.3年的70例MWFLs患者中，67例（96%）病变未出现进展；剩余3例病变进展轻微，均未发生恶性转化。 结论：质子泵抑制剂使用史、女性性别与年龄为MWFLs的危险因素。我们认为内镜医师应当充分认识这类病变。