Renal parameters.

KW, Kidney Weight; Na+, sodium, K+, potassium, eGFR, estimated Glomerular filtration rate; Values are the mean±sem. Non-parametric ANOVAs analysis with two factors allowed the evaluation of interaction between aging and genotype. Student's T test *, ** and *** p<0.01, p<0.001 and p<0.0001 respectively when comparing SHHF +/?vs. SHHFcp/cp at same time point; § p<0.05, §§ p<0.01 and §§§ p<0.001 to compare T14-mo vs T1.5-mo for a same genotype; N stands for the number of samples; ns stands for not significant.

KW为肾脏重量（Kidney Weight）；Na+为钠离子（sodium），K+为钾离子（potassium），eGFR为估算肾小球滤过率（estimated Glomerular filtration rate）；数据以平均值±标准误（mean±sem）呈现。采用双因素非参数方差分析（ANOVA），用以评估衰老与基因型之间的交互效应。通过学生t检验分析：*、**、***分别代表在同一时间点下比较SHHF +/?与SHHFcp/cp时，P<0.01、P<0.001、P<0.0001的显著性水平；§、§§、§§§分别代表在同一基因型下比较T14月龄（T14-mo）与T1.5月龄（T1.5-mo）时，P<0.05、P<0.01、P<0.001的显著性水平；N表示样本量，ns表示无统计学显著性。