Influence of Donor Human Milk versus Formula on the Microbiota of Late Preterm Infants

Background: Donor human milk (DHM), unlike formula, contains human milk oligosaccharides that act as prebiotics to help shape the gut microbiome. DHM is not routinely used in late preterm infants (LPIs, born between 34-36 6/7 weeks gestation) who are at risk for an unhealthy gut microbiome. Objective: Describe differences in the microbiome and clinical outcomes of LPIs fed donor human milk compared to infants exposed to formula early in life. Methods: LPIs were randomized to DHM or formula to supplement maternal breastmilk (MBM). Block randomization was by gestational age and delivery mode. Oral, skin, and stool samples were obtained daily until discharge to analyze the microbiome. Major clinical outcomes included length of stay (LOS), weight gain, and feeding tolerance were recorded. Results: Pending

背景：捐赠人乳（Donor human milk, DHM）与配方奶不同，其含有人乳低聚糖，可作为益生元帮助塑造肠道菌群。目前捐赠人乳并未常规应用于胎龄介于34至36又6/7周的晚期早产儿（late preterm infants, LPIs）群体，而该类婴儿存在肠道菌群异常的风险。
目的：对比早期暴露于配方奶的婴儿，分析食用捐赠人乳的晚期早产儿在肠道菌群特征与临床结局方面的差异。
方法：将晚期早产儿随机分组，分别以捐赠人乳或配方奶补充母乳（maternal breastmilk, MBM）。采用区组随机化设计，按胎龄与分娩方式进行分层。每日采集口腔、皮肤及粪便样本直至患儿出院，用于肠道菌群分析。记录的主要临床结局指标包括住院时长（length of stay, LOS）、体重增长情况与喂养耐受性。
结果：待发表