Parathyroid tissue transcriptome of control, untreated uremic and Cinacalcet-treated uremic rats at two timepoints

We investigate whether Cinacalcet treatment timed to the expression of its drug target; the Calcium-Sensing Receptor, could improve efficacy of treatment in secondary hyperparathyroidism. We found that proliferation rate of parathyroid glands of uremic rats was markedly reduced when Cinacalcet was administered in the early inactive phase compared to conventional timing early in the active phase. We use RNAseq of parathyroid tissue to investigate the possible mechanism behind this enhanced anti-proliferative effect.