Enhanced placental antibody transfer efficiency with longer interval between maternal respiratory syncytial virus vaccination and birth

We conducted a prospective cohort study at 2 academic medical centers between September 20, 2023 and March 21, 2024. Individuals who received the respiratory syncytial virus (RSV) vaccine were enrolled. Maternal and cord blood samples (dyads) were collected at delivery, and capillary blood samples were obtained from a subset of infants at 2 months of age. The study examined how gestational age at vaccination and the time elapsed from vaccination to delivery impacted the transfer of maternal antibodies to the fetus, measured in umbilical cord blood, and their persistence in infants peripheral blood at 2 months of age.

本研究于2023年9月20日至2024年3月21日期间，在2家学术医疗中心开展前瞻性队列研究。招募接种呼吸道合胞病毒（RSV）疫苗的受试者，于分娩时采集产妇与脐血配对样本，并在2月龄时从部分婴儿中采集毛细血管血样本。本研究旨在探究疫苗接种时的孕周、接种至分娩的间隔时长，对母体抗体向胎儿转运（以脐血检测结果为衡量标准）的影响，以及该抗体在婴儿外周血中2月龄时的留存水平。