Hippocampal stimulation during temporal lobe seizure

Four non-human primates were used for this study in two contemporaneous cohorts. One cohort (n=3 hemispheres) was implanted with the Medtronic RC+S stimulation (GIN cohort) and recording system connected to two 4-contact ring electrodes to evaluate three unilateral stimulation patterns: 7 Hz Ring ADMES, 20 Hz Dual Ring, and 125 Hz Dual Ring (analog of clinical stimulation). In an additional cohort (EPC cohort, n=2), two 12-contact segmented electrodes were implanted in the right hippocampus and connected to an externalized recording and stimulation system to allow more flexibility in the stimulation pattern. In this second cohort, 4 variations of stimulation were evaluated (7 Hz Full ADMES, 7 Hz Ring ADMES, 31 Hz Wide Ring, and 31 Hz Dual Ring).

本研究共纳入4只非人灵长类动物，分为两个同期队列。第一队列（GIN队列，n=3个大脑半球）植入美敦力（Medtronic）RC+S刺激记录系统，该系统连接2个4触点环形电极，用于评估3种单侧刺激模式：7Hz环形ADMES、20Hz双环形刺激、125Hz双环形刺激（临床刺激等效模式）。另一补充队列（EPC队列，n=2）中，2个12触点分段电极被植入右侧海马体，并连接至外置式记录刺激系统，以实现刺激模式的更高灵活性。在该第二队列中，共评估了4种刺激变体：7Hz全段ADMES、7Hz环形ADMES、31Hz宽环形刺激以及31Hz双环形刺激。