Chromatin Interaction Maps Reveal Genetic Regulation for Quantitative Traits in Maize

We characterized epigenetic features of active promoter proximal regions and candidate distal regulatory elements to construct high-resolution chromatin interaction maps for maize via long-read chromatin interaction analysis by paired-end tag sequencing (ChIA-PET). These maps provide an high-resolution view of 3D maize genome architecture, and its role in gene expression and phenotypic variation.本研究通过基于配对末端标签测序的长读长染色质相互作用分析（ChIA-PET），对玉米活性启动子近端区域与候选远端调控元件的表观遗传特征进行了表征，进而构建了玉米的高分辨率染色质相互作用图谱。这些图谱可为解析玉米三维基因组结构及其在基因表达与表型变异中的调控作用提供高分辨率视角。