Global endothelial function assessment using pulse wave analysis in hypercholesterolemia

Abstract To compare global endothelial function assessed by pulse wave analysis (PWA) using the ratio of endothelium dependent vasodilatation (EDV) to endothelium independent vasodilatation (EIV) in patients with hypercholesterolemia and controls. 92 subjects [46 hypercholesterolemics, 46 controls] were studied at standardized conditions. Baseline augmentation index (AIx) was assessed followed by the administration of 0.5 mg sublingual nitroglycerine, an endothelium independent vasodilator. AIx was assessed and the maximum change in AIx after nitroglycerine was recorded as EIV. After a washout period of 30 minutes, 400 µg of inhaled salbutamol, an endothelium dependent vasodilator was administered. AIx was assessed again and the maximum change in AIx after salbutamol was recorded as EDV. Global endothelial function was calculated as EDV:EIV ratio. EDV and EIV in patients with hypercholesterolemia compared to controls were 2.97 ± 3.95 and 6.65 ± 3.80 (p<0.001); and 13.41 ± 4.57 and 15.88 ± 4.78 (p=0.01) respectively. EDV:EIV ratio was significantly reduced in patients with hypercholesterolemia compared to controls; 0.21 ± 0.38 and 0.44 ± 0.24 (p<0.001) respectively. EDV:EIV ratio was significantly reduced in patients with hypercholesterolemia compared to controls. PWA is a potential clinical tool to assess global endothelial function in patients with hypercholesterolemia.

摘要 本研究旨在对比高胆固醇血症患者与健康对照者中，采用脉搏波分析（PWA）评估的以内皮依赖性血管舒张（EDV）与内皮非依赖性血管舒张（EIV）比值计算的全球内皮功能。本研究在标准化条件下纳入92名受试者（46名高胆固醇血症患者，46名健康对照者）进行研究。首先检测基线增强指数（AIx），随后给予0.5mg舌下硝酸甘油——一种内皮非依赖性血管舒张剂，再次检测AIx，并将硝酸甘油给药后AIx的最大变化值记为EIV。经过30分钟洗脱期后，给予400μg吸入沙丁胺醇——一种内皮依赖性血管舒张剂，再次检测AIx，并将沙丁胺醇给药后AIx的最大变化值记为EDV。全球内皮功能以EDV:EIV比值进行计算。高胆固醇血症患者与对照者的EDV及EIV分别为2.97±3.95与6.65±3.80（p<0.001），以及13.41±4.57与15.88±4.78（p=0.01）。高胆固醇血症患者的EDV:EIV比值显著低于对照者，分别为0.21±0.38与0.44±0.24（p<0.001）。高胆固醇血症患者的EDV:EIV比值较对照者显著降低。脉搏波分析（PWA）是一种潜在的临床工具，可用于评估高胆固醇血症患者的全球内皮功能。