Xenium and Methoxy-X04 stain data from six human AD donors

This dataset encompasses Xenium data from cortical tissue of six human AD donors, three homozygous for APOE3 and three homozygous for APOE4. After Xenium, the same sections were stained for amyloid beta plaques with methoxy-X04. The raw and processed data from Xenium as well as the full-slide scans from methoxy-X04 and SYTOX Green staining are shared here.

This data is associated with "An Exhausted-Like Microglial Population that Accumulates in Aged and APOE4 Genotype Alzheimer’s Brains", from Millet, Ledo et al..

本数据集包含6名人类阿尔茨海默病（Alzheimer's Disease, AD）供体的大脑皮层组织的Xenium空间转录组数据，其中3名为APOE3纯合子，另外3名为APOE4纯合子。经Xenium平台检测后，研究人员对同一组织切片使用甲氧基-X04（methoxy-X04）染色以标记β淀粉样蛋白斑块。本次共享了Xenium平台的原始与处理后数据，以及甲氧基-X04和SYTOX Green（SYTOX Green）染色的全玻片扫描图像。

本数据集关联的研究论文为《在衰老及APOE4基因型阿尔茨海默病大脑中富集的耗竭样小胶质细胞群》（"An Exhausted-Like Microglial Population that Accumulates in Aged and APOE4 Genotype Alzheimer’s Brains"），作者为Millet、Ledo等人。