Visible-Light Induced and Oxygen-Promoted Oxidative Cyclization of Aromatic Enamines for the Synthesis of Quinolines Derivatives

The
dual transition metal-visible light photoredox catalysis for
the synthesis of quinoline derivatives by using dioxygen as an oxygen
source is developed. By using visible light, the direct oxidative
cyclization of aromatic enamines with alkynes or alkenes can be achieved
at mild conditions with an aid of copper or palladium catalysts, and
a variety of multisubstituted quinoline derivatives could be obtained
in good to moderate yields under mild reaction conditions.

本研究开发了以氧气作为氧源，采用双过渡金属-可见光光氧化还原催化体系合成喹啉衍生物的方法。在可见光辐照下，借助铜或钯催化剂的辅助作用，可在温和反应条件下实现芳香烯胺与炔烃或烯烃的直接氧化环化，且能在温和条件下以良好至中等收率得到多种多取代喹啉衍生物。