Datasheet1_A systematic analysis of the global, regional, and national burden of fungal skin diseases from 1990 to 2021.zip

PurposeWe aimed to assess the burden of Fungal Skin Diseases (FSD) in 2021 and explore the changing trends from 1990 to 2021 across different age groups and time periods.
MethodsThis study extracted three key indicators of the burden of FSD from the Global Burden of Disease (GBD) 2021 study: prevalence, incidence, and disability-adjusted life years (DALYs). The results were presented using point estimates and Uncertainty Intervals (UIs), and secondary analysis was conducted on these data to assess the changing trends in the burden of FSD using percentage change.
ResultsIn 2021, the global cases of prevalence, incidence, and DALYs of FSD were reported at 616.5 million, 1,729.2 million, and 3,429.5 thousand, respectively, an increase of approximately 68% since 1990. The age-standardized rates per 100,000 population for prevalence, incidence, and DALYs were 7,789.6, 21,668.4, and 43.4, respectively. These rates represent percentage increases of 6.21%, 3.74%, and 6.56% since 1990. In terms of age distribution, the ages for FSD-related prevalence, incidence, and DALYs peak cases globally were in the 5–9 age group, with distinct age groups observed in low and low-middle, middle, high-middle and high SDI regions at 5–9 years, 45–49 years, and 70–74 years, respectively.
ConclusionOver the past 32 years, there has been a significant increase in the global burden of FSD. With improvements in the Socio-Demographic Index (SDI), the age groups for FSD-related peak cases are gradually shifting towards older age groups. This indicates the need to allocate healthcare resources rationally to address the challenges arising from the significant differences in geographic distribution, gender, and among different populations.

研究目的：本研究旨在评估2021年真菌性皮肤病（Fungal Skin Diseases, FSD）的疾病负担，并探讨1990年至2021年期间不同年龄组与时间段的变化趋势。
研究方法：本研究从2021年全球疾病负担（Global Burden of Disease, GBD）研究中提取FSD疾病负担的三项核心指标：患病率、发病率与伤残调整寿命年（Disability-Adjusted Life Years, DALYs）。研究结果以点估计值及不确定区间（Uncertainty Intervals, UIs）进行呈现，并通过百分比变化对上述数据开展二次分析，以评估FSD疾病负担的动态变化趋势。
研究结果：2021年，全球FSD的患病率、发病率及DALYs病例数分别为6.165亿、17.292亿及342.95万，较1990年增长约68%。每10万人口的年龄标化患病率、发病率及DALYs率分别为7789.6、21668.4及43.4，较1990年分别增长6.21%、3.74%及6.56%。从年龄分布维度来看，全球FSD相关患病率、发病率及DALYs病例数的峰值年龄段均为5~9岁；而低、中低、中、中高及高社会人口指数（Socio-Demographic Index, SDI）区域的峰值年龄段分别为5~9岁、45~49岁与70~74岁，存在显著差异。
研究结论：过去32年间，全球FSD的疾病负担已出现显著上升。随着社会人口指数（SDI）的提升，FSD相关病例数峰值的年龄组正逐步向高龄群体偏移。这提示需合理配置医疗资源，以应对地理分布、性别及不同人群间显著差异所带来的公共卫生挑战。