Total Synthesis of (−)-Luminacin D
收藏Figshare2016-05-02 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Total_Synthesis_of_Luminacin_D/3181408
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A second-generation synthesis of (−)-luminacin D based on an early stage introduction of the trisubstituted epoxide group is reported, allowing access to the natural product in an improved yield and a reduced number of steps (5.4%, 17 steps vs 2.6%, 19 steps). A full account of the optimization work is provided, with the reversal of stereoselection in the formation of the C4 alcohol in equally excellent diastereoselectivity as the key improvement.
创建时间:
2016-05-02



