Data_Sheet_1_Corneal stromal mapping characteristics in normal corneas using anterior segment SD-OCT.docx

This study investigated how normal corneal stromal profiles change with age, sex, and corrected intraocular pressure (IOP). A retrospective observational analytical study was conducted in Jordan, employing anterior segment spectral-domain optical coherence tomography AS-OCT, a measured corneal stromal thickness (CST) in 134 eyes across the central 6-mm corneal diameter. People between the ages of 18 and 79 were included, and the mean CST values were linked to age groups, IOP, and cis-gender populations, with the exclusion of certain eye conditions. The central stroma was thinnest at 484.6 (±32.6) μm, contrasting with the outer peripheral superior zone’s maximum thickness at 549.3 (±40.6) μm. A positive correlation between CST and the 30–49 age group was noted. In conclusion, this study highlights a centrifugal CST distribution, with the central stroma being the thinnest and the superior stroma being the thickest. AS SD-OCT, employing novel algorithms, proves vital in refractive surgery planning and corneal disease diagnosis. The research offers valuable insights into age, gender, and IOP interactions with corneal stromal characteristics, enhancing clinical strategies for corneal pathologies in the Jordanian population.

本研究旨在探讨正常角膜基质轮廓随年龄、性别及校正后眼压（corrected intraocular pressure, IOP）的变化规律。本研究为一项在约旦开展的回顾性观察分析研究，采用前节光谱域光学相干断层扫描（anterior segment spectral-domain optical coherence tomography, AS-OCT）技术，对中央6mm角膜直径范围内的134只眼的角膜基质厚度（corneal stromal thickness, CST）进行了测量。研究纳入18至79岁的受试者，将平均角膜基质厚度值与年龄组、眼压及顺性别人群进行关联分析，并排除了合并特定眼部疾病的受试者。结果显示，中央角膜基质厚度最薄，为484.6（±32.6）μm，而上方外周区域的基质厚度最大，为549.3（±40.6）μm；同时观察到角膜基质厚度与30~49岁年龄组呈正相关。本研究揭示了角膜基质呈现离心性分布特征，即中央基质最薄、上方基质最厚。采用新型算法的前节光谱域光学相干断层扫描（AS-OCT）在屈光手术规划与角膜疾病诊断中具有重要应用价值。本研究为阐明年龄、性别与眼压对角膜基质特性的影响提供了宝贵见解，有助于优化约旦人群角膜病变的临床诊疗策略。