GADD45 promotes locus specific DNA demethylation and 2C cycling in embryonic stem cells

Mouse embryonic stem cell cultures contain a rare cell population of "2C-like" cells resembling 2-cell embryos, the key stage of zygotic genome activation (ZGA). Little is known about positive regulators of the 2C-like state and 2-cell stage embryos. We found that GADD45 (growth arrest and DNA damage 45) proteins, regulators of TET mediated DNA demethylation, promote both states. This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

小鼠胚胎干细胞培养物中存在一类稀有“2C样”细胞群体，其表型类似合子基因组激活（zygotic genome activation, ZGA）的关键阶段——2细胞胚胎。目前学界对2C样状态及2细胞期胚胎的正向调控因子仍知之甚少。本研究发现，作为TET介导DNA去甲基化调控因子的GADD45（生长抑制与DNA损伤诱导蛋白45, growth arrest and DNA damage 45），可同时促进这两种状态的形成。本SuperSeries由下述SubSeries组成，请参阅各独立Series。