Vector Venom: Venomics of Aedes albopictus reveals a large enzyme repertoire and novel cecropins with activity against E. coli

Mosquitoes, particularly the Asian tiger mosquito (Aedes albopictus), are significant vectors for various diseases. This project aims to conduct a comprehensive venomics study of Ae. albopictus venom to deepen our understanding of its biochemical properties. Our methodology included the identification and characterization of the venom's protein components through RNA sequencing (RNA-seq) transcriptomics. We validated our findings using mass spectrometry analysis of crude venom, ensuring accurate identification of the venom proteins. This integrative approach allowed us to explore the complex biochemical landscape of mosquito venom.

蚊虫，尤其是亚洲虎蚊（Aedes albopictus），是多种疾病的重要传播媒介。本项目旨在针对亚洲虎蚊的毒液开展全面的毒液组学（venomics）研究，以深化对其生化特性的理解。本研究采用的方法包括通过RNA测序（RNA-seq）转录组学（transcriptomics）技术，对该毒液的蛋白质组分进行鉴定与表征。我们通过对粗制毒液开展质谱分析以验证研究发现，确保了毒液蛋白鉴定结果的准确性。这种整合式研究方法助力我们深入解析了蚊虫毒液复杂的生化特征图谱。