NORWAY BAG

The fourteen PIs associated to this proposal represent the entire crystallography community in Norway and are affiliated to the major Norwegian universities. The research interests of the PIs and their collaborators revolves around topics linked to structural biology and material sciences.

We apply for beam time for single- and multi-wavelength MX, Bio-SAXS and Cryo-EM, in support of our research projects funded e.g. by the Research Council of Norway and the ERC. Examples of research projects or topics are carbohydrate-active proteins of medical or bioeconomic relevance, inhibition of DNA repair enzymes, metalloprotein function and catalysis, regulation of cell-cycle processes, enzyme discovery, antibiotic resistance/drug-discovery and neurological diseases.

Our overarching aim is to use bright synchrotron sources to produce high quality science.

参与本提案的14位项目负责人（Principal Investigators，PIs）代表了挪威全境的晶体学研究共同体，且均隶属于挪威主要高校。项目负责人及其合作者的研究方向围绕结构生物学与材料科学相关议题展开。
我们申请同步辐射光束线机时，用于单波长与多波长大分子晶体学（Macromolecular Crystallography，MX）、生物小角X射线散射（Bio-SAXS）以及冷冻电子显微镜（Cryo-EM）实验，以支撑由挪威研究理事会、欧洲研究理事会（European Research Council，ERC）等机构资助的研究项目。本团队的研究项目与主题示例包括：具有医学或生物经济价值的碳水化合物活性蛋白、DNA修复酶抑制机制、金属蛋白功能与催化作用、细胞周期过程调控、酶的发掘、抗生素耐药性/药物研发以及神经系统疾病相关研究。
我们的核心目标是借助高亮度同步辐射光源产出高质量的科研成果。