G-CSF SECRETED BY EPIGENETICALLY REPROGRAMMED MUTANT IDH1 GLIOMA STEM CELLS, REVERSES THE MYELOID CELLS'-MEDIATED IMMUNOSUPPRESSIVE TUMOR MICROENVIRONMENT [Run2961]. G-CSF SECRETED BY EPIGENETICALLY REPROGRAMMED MUTANT IDH1 GLIOMA STEM CELLS, REVERSES THE MYELOID CELLS'-MEDIATED IMMUNOSUPPRESSIVE TUMOR MICROENVIRONMENT [Run2961]

Study the impact of IDH1 mutation in glioma on the tumor infiltrating myeloid cells phenotype and function Overall design: Dissecting tumor heterogeneity in genetically engineered glioma mouse models expressing IDH1 mutation

本研究旨在探究胶质瘤中异柠檬酸脱氢酶1（IDH1）突变对肿瘤浸润髓系细胞表型与功能的影响。实验整体设计：采用表达IDH1突变的基因工程改造胶质瘤小鼠模型，解析肿瘤异质性。