The Relationship Between Circulating Tumor Cells in Peripheral Blood and Clinical Characteristics of Pediatric Neuroblastoma and Prognostic Evaluation

This retrospective analysis included 144 children with advanced NB who received comprehensive treatment from September 2020 to October 2022. Detailed clinical data of the patients were collected, and CTCs in samples were detected using a negative enrichment method based on immunomagnetic beads adsorption combined with immunofluorescence technology. The prognostic evaluation criteria and cut-off values for CTCs were determined using the ROC curve method. Furthermore, univariate and Cox multivariate regression analyses were used to identify independent risk factors affecting the prognosis of children with NB.