1Values are presented as mean (SEM) or (SED) for differences between week 16 and week 4. 2Differences at baseline between groups were assessed by using two-factor ANOVA on log-transformed values. 3Dif
aBoundary condition “True” for a metabolite indicates that its concentration is not determined by the set of reactions even when that metabolite occurs as a substrate or product i.e., the metabolite i
