Additional file 6 of Concentrations of persistent organic pollutants in maternal plasma and epigenome-wide placental DNA methylation

Additional file 6: Supplementary Tables: Table S1. Characteristics of the study subsample and of the full NICHD fetal Growth Studies – Singletons. Table S2: Description of the maternal plasma persistent organic pollutants concentrations. TableS3: Top-significant adjusted difference (BACON-corrected FDR p-values < 0.05) in placenta DNA methylation associated with maternal POP. Table S4: Differentially methylated regions (DMR) analysis. TableS5: Correlations between DNA methylation at the top differentially methylated CpG sites and gene expression in placenta. Table S6: Significant associations between maternal blood levels of POP and expression of genes near the top significant DNA methylation CpG sites. Table S7: Top 10 pathways of diseases and biological function from IPA. TableS8: IPA Canonical Pathway. Table S9: Network identified by Ingenuity Pathway Analysis. Table S10: Placental cis-eQTL analysis of top-significant (Bacon-adjusted FDR P-value<0.05) CpGs. Table S11: Cis-meQTL analysis of top-significant (Bacon-adjusted FDR P-value<0.05) CpGs. Table S12: Spearman correlation between top differentially methylated CpG sites and neonatal anthropometry. Table S13: Spearman correlation between neonatal anthropometry and gene-expression that were significantly correlated with the methylation on the corresponding CpG sites. Table S14: Comparison with previous EWAS on chemicals. Table S15: Sensibility analysis further adjusted for clinical sites for the CpG sites differentially methylated in the original model.附加文件6：补充附表：表S1 研究子样本与完整NICHD胎儿生长研究单胎队列的特征；表S2 母体血浆持久性有机污染物（persistent organic pollutants, POPs）浓度概况；表S3 与母体POP相关的胎盘DNA甲基化中经校正的最显著差异（经BACON校正的FDR P值<0.05）；表S4 差异甲基化区域（Differentially Methylated Regions, DMR）分析；表S5 胎盘组织中最显著差异甲基化CpG位点的DNA甲基化水平与基因表达的相关性；表S6 母体血液POP水平与最显著DNA甲基化CpG位点附近基因表达的显著关联；表S7 来自Ingenuity通路分析（Ingenuity Pathway Analysis, IPA）的前10种疾病与生物学功能通路；表S8 IPA经典通路；表S9 Ingenuity通路分析（IPA）鉴定得到的调控网络；表S10 最显著（经BACON校正的FDR P值<0.05）CpG位点的胎盘顺式表达数量性状位点（cis-eQTL）分析；表S11 最显著（经BACON校正的FDR P值<0.05）CpG位点的顺式甲基化数量性状位点（cis-meQTL）分析；表S12 最显著差异甲基化CpG位点与新生儿人体测量学指标的斯皮尔曼相关性；表S13 新生儿人体测量学指标与对应CpG位点甲基化水平显著相关的基因表达的斯皮尔曼相关性；表S14 与既往化学物质相关表观基因组全关联研究（Epigenome-Wide Association Study, EWAS）的对比；表S15 针对原始模型中差异甲基化CpG位点，按临床中心进一步校正的敏感性分析