Molecular distinctions between proprioceptors supplying Tibialis anterior (TA) and Gastrocnemius (GS) muscles [array]. Mus musculus

Muscle-specific populations of proprioceptive sensory neurons form selective connections with spinal motor neurons, implying the existence of molecular distinctions between proprioceptor subpopulations. Here, we compare the gene expression profiles of proprioceptors that supply an antagonistic muscle pair functioning at a single hindlimb joint. Overall design: TA and GS muscles in a Pv::YFP reporter line were injected at p0 with ctb-555; retrogradely labeled proprioceptors were manually isolated at p1 and pooled to form 25-30 neuron samples. *** Processed data (i.e., Partek-generated log2 GCRMA signals) are unavailable. ***

肌肉特异性本体感觉感觉神经元（proprioceptive sensory neurons）群体与脊髓运动神经元（spinal motor neurons）形成选择性连接，提示本体感受器（proprioceptor）亚群之间存在分子层面的差异。本研究对比了支配单一后肢关节处拮抗肌对的本体感受器的基因表达谱。
实验设计：于出生后0天（p0）向Pv::YFP报告基因小鼠品系的胫骨前肌（TA）与腓肠肌（GS）注射ctb-555（霍乱毒素亚基B-555）；于出生后1天（p1）手动分离逆行标记的本体感受器，并将其混合为25~30个神经元的样本。
*** 已处理数据（即Partek生成的log2转换的基因芯片稳健多阵列分析（GCRMA）信号）无法获取。***