Transcriptional regulation of Sox17 in HUVEC. Homo sapiens

We identified Sox17 as a novel angiogenic transcription factor in the context of tumor. Our data revealed that Sox17 promotes tumor angiogenesis and tumor vessel abnormality. We found that Sox17 is specifically expressed in tumor endothelial cells within tumors. Our study elucidates a novel transcriptional regulation for tumor angiogenesis Overall design: Control HUVECs vs. Sox17 knockdown HUVECs. Biological replicates: 3 control replicates, 3 transfected replicates.

我们鉴定出Sox17是肿瘤背景下一种新型血管生成转录因子。本研究数据表明，Sox17可促进肿瘤血管生成并引发肿瘤血管异常。我们发现，Sox17特异性表达于肿瘤内部的肿瘤内皮细胞中。本研究阐明了调控肿瘤血管生成的新型转录调控机制。
实验设计：对照组为人脐静脉内皮细胞（Human Umbilical Vein Endothelial Cells，HUVECs），实验组为Sox17敲低的人脐静脉内皮细胞。
生物学重复：设置3个对照重复样本与3个转染敲低重复样本。