LRP8-Reelin-regulated Neuronal (LRN) Enhancer signature underlying learning and memory formation (RNA-Seq 1)

A comprehensive landscape of epigenomic events regulated by the Reelin signaling through activation of specific cohort of cis-regulatory enhancer elements (LRN-enhancers), which involves the proteolytical processing of the LRP8 receptor by the gamma-secretase activity and is required for learning and memory behavior All RNA-Seq experiments were designed to evaluate the transcriptional program regulated by the Reelin-LRP8 signaling pathway in neuronal cells

本数据集全面呈现了瑞林信号通路（Reelin）通过激活特定顺式调控增强子元件群组（LRN-enhancers）所调控的表观基因组事件全景图谱。该调控过程涉及γ-分泌酶活性介导的LRP8受体蛋白水解加工，且为学习与记忆行为所必需。所有RNA测序（RNA-Seq）实验均旨在评估神经元细胞中由瑞林-LRP8信号通路调控的转录程序。