Additional file 4 of Polygenic risk scores indicate extreme ages at onset of breast cancer in female BRCA1/2 pathogenic variant carriers

Additional file 4 SNPs included in polygenic risk score (PRS) computation, corresponding per-allele log odds ratios, and comparison of allele frequencies between patients recruited by Sheba Medical Center, Tel Aviv University (AF Sheba) and patients recruited by the German Consortium for Hereditary Breast and Ovarian Cancer (AF GC-HBOC).

补充文件4包含用于多基因风险评分（polygenic risk score, PRS）计算的单核苷酸多态性（Single Nucleotide Polymorphisms, SNPs）、对应的每等位基因对数优势比，以及特拉维夫大学舍巴医学中心招募的患者的等位基因频率（记为AF Sheba）与遗传性乳腺癌和卵巢癌德国联盟招募的患者的等位基因频率（记为AF GC-HBOC）之间的对比。