Genome-wide map of H3K27Ac chromatin state in CRISPR/Cas9 negative control and AP-1 depleted human uterine smooth muscle cells (HUtSMCs).

We report that the loss of AP-1 subunit gene expression leads to alterations in enhancer H3K27Ac enrichment. Altered distal enhancer regions are shown to overlap significantly with AP-1 DNA binding motifs. Examination of the genome-wide histone modification H3K27Ac signal in AP-1 depleted human uterine smooth muscle cells (HUtSMCs).

我们在此报道，AP-1亚基基因的表达缺失会引发增强子H3K27乙酰化（H3K27Ac）富集状态的改变。研究表明，发生异常改变的远端增强子区域与AP-1 DNA结合基序存在显著重叠。本研究对AP-1敲低的人子宫平滑肌细胞（HUtSMCs）中的全基因组组蛋白修饰H3K27乙酰化（H3K27Ac）信号进行了检测分析。