Increased spatial coupling of integrin and collagen IV in the immunoresistant clear cell renal cell carcinoma tumor microenvironment

Data export from Nanostring CosMx SMI, directly from Nanostring, in Seurat Object format for use in R. Clear cell renal cell carcinoma and papillary renal cell carcinoma were profiled before and after exposure to immunotherapy, with and without sarcomatoid features in clear cell tumors. Each tumor had a field of view in the stromal compartment and field of view in the tumor compartment. For appropriate clinical information associated with this study, please contact Dr. Brandon Manley.

本数据集为直接由Nanostring公司导出的Nanostring CosMx SMI数据文件，采用可适配R语言的Seurat对象（Seurat Object）格式存储。本研究针对透明细胞肾细胞癌与乳头状肾细胞癌展开分子表征分析，涵盖免疫治疗干预前后的样本；其中透明细胞肾细胞癌样本同时包含带有肉瘤样特征与不带有肉瘤样特征的组别。每一例肿瘤均设置了间质区域与肿瘤区域两个观测视野。如需获取本研究相关的完整临床信息，请联系布兰登·曼利博士（Dr. Brandon Manley）。