BindingDB Entry 50001444: Discovery of novel anti-angiogenesis agents. Part 7: Multitarget inhibitors of VEGFR-2, TIE-2 and EphB4.

Small molecule binding data for protein BRAF/CRAF, Ephrin type-B receptor 4, Epidermal growth factor receptor, Fibroblast growth factor receptor 1, Fibroblast growth factor receptor 4, Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, Hepatocyte growth factor receptor, Insulin-like growth factor I receptor, Mast/stem cell growth factor receptor Kit, VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta), Vascular endothelial growth factor receptor 1, and Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), Uniprot A0A024R759, L7RSL3, P00533, P08069, P08581, P09619, P10721, P11362, P15056, P17948, P22455, P35916, P35968, P54760, Q02763, and Q541P7

本数据集涵盖针对下述靶标蛋白的小分子结合数据：BRAF/CRAF蛋白、Ephrin B型受体4（Ephrin type-B receptor 4）、表皮生长因子受体（Epidermal growth factor receptor）、成纤维细胞生长因子受体1、成纤维细胞生长因子受体4、黏着斑激酶1/血管内皮生长因子受体3、肝细胞生长因子受体（Hepatocyte growth factor receptor）、胰岛素样生长因子I型受体（Insulin-like growth factor I receptor）、肥大细胞/干细胞生长因子受体Kit（Mast/stem cell growth factor receptor Kit）、血管内皮生长因子受体2与血小板衍生生长因子受体β（KDR与PDGFRβ）、血管内皮生长因子受体1（Vascular endothelial growth factor receptor 1）、血管内皮生长因子受体2与酪氨酸蛋白激酶TIE-2（KDR与TIE2），以及通用蛋白质知识库（UniProt）编号为A0A024R759、L7RSL3、P00533、P08069、P08581、P09619、P10721、P11362、P15056、P17948、P22455、P35916、P35968、P54760、Q02763及Q541P7的蛋白。