Analysis of transgenerational effects on DNA copy number aberrations in male mice exposed to continuous 20mGy/day gamma-rays for 400 days (Secondary screening for 20mGyH familly).. Mus musculus

Transgenerational effects of continuous low dose-rate (LDR) gamma-ray irradiation have not been well studied. C57BL/6JNrs male mice were maintained in non-irradiated room for 400 days from 8 weeks of age. This study investigated the De novo mutation by comparing the parents and children. This is secondary screening. This study was performed under contract with the Aomori Prefectural Government, Japan. Overall design: Two-condition experiment, C57 BL/6JNrs tail tissue non-irradiated male (20mGyHM), female (20mGyHF) and their progenies (20mGyH1 to 20mGyH6) vs. reference male mouse.

持续低剂量率（LDR）γ射线辐照的跨代效应尚未得到充分研究。C57BL/6JNrs雄性小鼠自8周龄起于无辐照环境中饲养400天。本研究通过比对亲代与子代样本，对新发突变（de novo mutation）进行了探究。本次分析属于二次筛选实验。本研究受日本青森县政府委托开展。实验整体设计为双条件对照实验：以C57 BL/6JNrs尾组织来源的非辐照雄性小鼠（20mGyHM）、雌性小鼠（20mGyHF）及其子代（20mGyH1至20mGyH6）为受试对象，与参考雄性小鼠进行对照比较。