Dataset from A Phase 3b/4 Randomized Double Blind Study Of 5 Mg Of Tofacitinib With And Without Methotrexate In Comparison To Adalimumab With Methotrexate In Subjects With Moderately To Severely Active Rheumatoid Arthritis

To assess the efficacy of tofacitinib monotherapy or tofacitinib with methotrexate as
compared to adalimumab with methotrexate. To compare the efficacy of tofacitinib monotherapy
compared to tofacitinib combined with methotrexate. To compare effects on all health outcomes
measures in the study. To evaluate the safety and tolerability of tofacitinib and adalimumab.
To evaluate the safety of the zoster vaccine given prior to the initiation of tofacitinb or
adalimumab.

本研究旨在达成以下目标：一是评估托法替布（tofacitinib）单药治疗、托法替布联合甲氨蝶呤（methotrexate）对比阿达木单抗（adalimumab）联合甲氨蝶呤的疗效；二是对比托法替布单药治疗与托法替布联合甲氨蝶呤的疗效；三是比较不同干预措施对本研究中所有健康结局指标的影响；四是评估托法替布与阿达木单抗的安全性与耐受性；五是评估在启动托法替布或阿达木单抗治疗前接种带状疱疹疫苗（zoster vaccine）的安全性。