Systematic Review Dataset on Environmental Enrichment Effects on BDNF in ASD Models

We have compiled a dataset for a systematic review on the effect of environmental enrichment (EE) on brain-derived neurotrophic factor (BDNF) activity in animal models of autism spectrum disorder (ASD). This dataset allows for a comprehensive analysis of EE's impact on BDNF expression and related behavioral outcomes, focusing on variability across experimental conditions and study designs.

The dataset includes articles identified through systematic searches in multiple databases (PubMed, Scopus, and Web of Science), organized across key stages of the review process:

- Keywords and Search Strategies: This document includes all search terms and Boolean operators used across databases to ensure transparency and reproducibility.
- All retrieved articles: A complete list of studies identified using pre-defined search strategies.
- Articles after removing duplicates: A refined dataset excluding duplicate records.
Retained articles after Title and Abstract screening: Results of title and abstract screening based on inclusion and exclusion criteria.
- Excluded studies after Full-text screening and reasons for exclusion.

The results revealed variability in the effects of EE on BDNF activity and behavioral outcomes. Factors such as the type of ASD model, EE protocols, sex of the animals, and brain regions examined significantly influenced the observed outcomes. Increased BDNF expression emerged as a key mechanism underlying EE’s impact on ASD-associated behaviors.

本数据集针对孤独症谱系障碍（ASD）动物模型中环境富集（Environmental Enrichment, EE）对脑源性神经营养因子（BDNF）活性的影响构建，用于开展相关系统综述研究。本数据集可支持对EE影响BDNF表达及相关行为学结局的全面分析，重点关注不同实验条件与研究设计下的效应异质性。

本数据集收录了通过PubMed、Scopus及Web of Science等多数据库系统检索得到的文献，并按综述流程的关键阶段进行分类整理：
- 关键词与检索策略：本文件涵盖所有数据库中使用的检索词与布尔逻辑运算符，以确保检索流程的透明度与可重复性。
- 全部检索所得文献：基于预设检索策略识别的所有研究的完整清单。
- 去重后文献：剔除重复记录后的精炼数据集。
- 标题与摘要筛选后留存文献：基于纳入排除标准完成标题与摘要筛选后的结果。
- 全文筛选后排除的研究及排除原因。

研究结果显示，EE对BDNF活性及行为学结局的效应存在显著异质性。孤独症谱系障碍模型类型、环境富集方案、实验动物性别以及所检测脑区等因素，均对观测结果产生显著影响。BDNF表达上调被证实为EE改善孤独症谱系障碍相关行为的核心作用机制。