Completion rate by demographic characteristics.

Hepatitis-B-Virus (HBV) remains an important global public health concern, as well as a primary cause of both acute and chronic liver diseases, with over 18 million people infected by the virus in Nigeria. This study evaluated the impact of HIV status, age, and gender of high-risk populations on HBV vaccination adherence and completion rate in Lagos state, Nigeria. A retrospective study design was utilized to access the clinic data of 641 study participants who participated in the HBV program at the one-stop-shop clinic between June 2021 to June 2024. Data on age, HIV status, gender, population type, and the date of each dose of administered vaccine were recorded. To estimate the odds-ratios (ORs) and adjusted-ORs at 95% confidence intervals (CIs), bivariate/multivariate logistic regression models were utilized, and the association between age, gender, HIV status, and HBV vaccination adherence and the completion rate was examined. The study participants had a mean age of 21.7 ± 8.8 years and were composed of 510 (79.6%) males, 131 (20.4%) females; 162 (25.3%) participants living with HIV, 423 (66.0%) HIV-negative participants, 500 (78.0%) MSM, and 115 (17.9%) FSW. The overall vaccination completion rate was 45.4%, with significant variation by age group (p = 0.004). The highest completion rates were observed among participants aged 30–34 years (58.4%) and 35–39 years (57.8%), while younger participants aged 15–29 had lower adherence. Gender and HIV status were not independently associated with vaccination completion (p > 0.05). Age was the only factor significantly affecting completion (AOR: 1.92, 95% CI: 1.23, 3.03). HBV vaccination coverage in high-risk populations is low in Lagos State. This suggests that the HBV vaccination program in the state is still facing significant challenges. Creating awareness about HBV infection and strengthening the availability, accessibility, and cost effectiveness of HBV service uptake will enhance the program's success.乙型肝炎病毒（Hepatitis-B-Virus，HBV）仍是全球重要的公共卫生议题，同时也是急慢性肝脏疾病的首要致病原因，尼日利亚境内现有超过1800万病毒感染者。本研究以尼日利亚拉各斯州的高危人群为研究对象，评估了HIV感染状态、年龄与性别对乙型肝炎疫苗接种依从性及完成率的影响。本研究采用回顾性研究设计，调取了2021年6月至2024年6月期间，在一站式门诊参与乙肝疫苗接种项目的641名研究对象的临床数据。研究记录了研究对象的年龄、HIV感染状态、性别、人群类型以及每剂疫苗的接种日期。为估算比值比（odds-ratios，ORs）与95%置信区间（confidence intervals，CIs）下的校正比值比（adjusted-ORs），本研究采用了双变量/多变量logistic回归模型，并分析了年龄、性别、HIV感染状态与乙肝疫苗接种依从性及完成率之间的关联。本次研究的对象平均年龄为21.7±8.8岁，其中男性510名（占比79.6%）、女性131名（占比20.4%）；HIV感染者162名（占比25.3%）、HIV阴性者423名（占比66.0%）；男男性行为者（MSM）500名（占比78.0%）、性工作者（FSW）115名（占比17.9%）。整体疫苗接种完成率为45.4%，且不同年龄组间存在显著统计学差异（p=0.004）。其中，30~34岁年龄组与35~39岁年龄组的接种完成率最高，分别为58.4%与57.8%，而15~29岁的年轻群体接种依从性较低。性别与HIV感染状态与疫苗接种完成率无独立关联（p>0.05）。年龄是唯一对疫苗接种完成率具有显著影响的因素（校正比值比：1.92，95%置信区间：1.23~3.03）。拉各斯州高危人群的乙肝疫苗接种覆盖率较低，提示该州的乙肝疫苗接种项目仍面临诸多严峻挑战。加强乙型肝炎病毒感染的健康宣教，提升乙肝疫苗接种服务的可及性、可获得性与成本效益，将有助于提升该项目的实施成效。