DataSheet1_Extracellular vesicles in the treatment of oxidative stress injury: global research status and trends.docx

Objective: The aim of this study was to conduct a bibliometric analysis of the literature on “Extracellular Vesicles in the Treatment of Oxidative Stress Injury” and to reveal its current status, hot spots and trends.
Methods: The relevant literature was obtained from the Web of Science Core Collection (WoSCC) on 29 April 2023. We performed clustering and partnership analysis of authors, institutions, countries, references and keywords in the literature through CiteSpace software and the bibliometric online analysis platform and mapped the relevant knowledge maps.
Results: A total of 1,321 relevant publications were included in the bibliometric analysis, with the number of publications in this field increasing year by year. These included 944 “articles” and 377 “reviews”. The maximum number of publications published in China is 512, and the maximum number of highly cited publications published in the United States is 20. Based on CiteSpace, the country collaboration network map shows close and stable collaboration among high-productivity countries. Based on WoSCC, there are 1706 relevant research institutions and 119 highly cited elite institutions, among which Kaohsing Chang Gung Men Hosp has the most extensive influence. Studies related to “Extracellular Vesicles in the Treatment of Oxidative Stress Injury” have been published in 548 journals. The keywords of the publications show the main research areas and breakthroughs. Based on WoSCC, the keywords of the research area “Extracellular Vesicles in the Treatment of Oxidative Stress Injury” were found to be as follows: exosome(s), extracellular vesicle(s), oxidative stress, inflammation, mesenchymal stem cells, apoptosis, microRNA (miRNA), mitochondria, biomarker, autophagy, angiogenesis and Alzheimer’s disease. Analysis showed that “mesenchymal stem cells”, “microRNA”, “autophagy”, “histology” and “therapeutic” emerged as highly explosive keywords.
Conclusion: This study is the first to use visual software and data mining to assess the literature in the field of “Extracellular Vesicles in the Treatment of Oxidative Stress Injury”. The research history, research status and direction in this field provide a theoretical basis for its scientific research.

研究目的：本研究旨在针对“氧化应激损伤治疗中的细胞外囊泡（Extracellular Vesicles）”相关文献开展文献计量学分析，以揭示该领域的研究现状、热点方向与发展趋势。
研究方法：本研究于2023年4月29日从Web of Science核心合集（Web of Science Core Collection, WoSCC）中检索获取相关文献。借助CiteSpace软件与文献计量在线分析平台，对文献中的作者、研究机构、国家、参考文献及关键词进行聚类与合作关系分析，并绘制相应知识图谱。
研究结果：本次文献计量分析共纳入1321篇相关文献，该领域发文量逐年攀升，其中期刊论文944篇、综述类文献377篇。中国以512篇发文量位居全球首位，美国高被引文献数量最多，达20篇。基于CiteSpace生成的国家合作网络图谱显示，高发文量国家间合作紧密且态势稳定。通过WoSCC检索可知，该领域涉及1706家相关研究机构与119家高被引精英机构，其中高雄长庚纪念医院（Kaohsing Chang Gung Men Hosp）的学术影响力最为广泛。“氧化应激损伤治疗中的细胞外囊泡”相关研究成果已发表于548种学术期刊。文献关键词可反映该领域的核心研究方向与突破性进展，经WoSCC分析，该领域的高频关键词包括：外泌体（exosome）、细胞外囊泡（extracellular vesicle）、氧化应激、炎症、间充质干细胞（mesenchymal stem cells）、细胞凋亡（apoptosis）、微小RNA（microRNA, miRNA）、线粒体（mitochondria）、生物标志物（biomarker）、自噬（autophagy）、血管生成（angiogenesis）与阿尔茨海默病（Alzheimer’s disease）。分析表明，“间充质干细胞”“微小RNA”“自噬”“组织学”与“治疗”为该领域的高爆发性关键词。
研究结论：本研究首次借助可视化软件与数据挖掘技术，对“氧化应激损伤治疗中的细胞外囊泡”领域的文献进行系统性评估。该领域的研究历程、现状与发展方向可为后续相关科学研究提供理论支撑。