Estimates for vaccine uptake models.

During a novel pandemic, significant uncertainty drives individuals to seek expert guidance on preventive measures such as vaccination. Yet, it remains poorly understood how people process information in a highly complex landscape of global health governance where multiple experts may offer competing, repetitive, or contradictory advice. This study investigates the influence of World Health Organization (WHO)’s endorsements of vaccines amidst this environment. In fall 2020, we conducted a randomized conjoint experiment in Canada (832 respondents, 8,320 profiles evaluated), Japan (1,474, 14,740), and the United States (1,001, 10010), focusing on both whether and when people choose to vaccinate against COVID-19. Our experiment randomly varied exposure to vaccine endorsement information from several prominent global health governance players, including the WHO, the Centers for Disease Control and Prevention (CDC), Oxford University, and the Gates Foundation; and, unlike previous studies, different combinations of these endorsements were used. WHO endorsements increase individuals’ willingness to vaccinate more quickly, even when accompanied by endorsements from other credible organizations. However, the effect of WHO endorsements is not significantly stronger than that of other organizations. Notably, the impact of the WHO’s endorsement diminishes as the number of endorsements from other organizations increases. The WHO has the greatest impact when it is the first (or among the first) of many organizations to endorse a vaccine as safe and effective, and it may help inspire public confidence in less effective (but potentially lifesaving) vaccines. Overall, our study shows that WHO endorsements significantly reduce vaccine hesitancy, but endorsements from other global actors can exert comparable effects. This highlights that effective global health communication thus depends not on a single authoritative voice but on the timely coordination of multiple credible actors, underscoring the resilience of the global health system in promoting vaccine acceptance.