Cost estimation.

1Costs for dental diagnostics (items 01, 8, Ä925) not included.
2Two-surface restoration assumed.
3Treatment of three root canals per tooth assumed.
For each course of treatment, costs were calculated by quantification of item-fees from public or private item-catalogues (for details see Supporting Information). Within the base-case scenario, non-invasive treatment accrued costs of 1/12 item-fee for fluoridation, since we assumed that all posterior interdental areas would be fluoridated. Within the high-costs scenario, non-invasive treatment generated full costs for topical fluoridation, and a higher fee-multiplicator (×3.5) was used for factorable items of the initial therapy to reflect cost-variability. Future costs were discounted with 3% per annum.

1. 牙科诊断费用（项目01、8、Ä925）未纳入核算范围。
2. 假设采用双面修复术。
3. 假设每颗牙齿需完成3个根管的治疗。

本研究针对每一疗程，通过公共或私人项目收费目录中的项目费用量化核算治疗成本（详细说明参见补充材料）。在基准情景下，非侵入性治疗的氟化治疗成本取项目费用的1/12，这是由于假设所有后牙邻间隙均实施了氟化处理。在高成本情景下，非侵入性治疗需全额支付局部氟化治疗费用，且初始治疗的可计费项目采用3.5倍的费用乘数，以体现成本的变异性。未来发生的成本按每年3%的比率进行折现。