BGN regulated colorectal cancer progress through modulating IL-10 secretion from enteric neurons and maintaining of gut microbiota ecosystem

To evaluate the effects of BGN deficiency on gut microbiota in AOM/DSS-treated WT and BGN (-/0) mice, feces samples were subjected to high-throughput sequencing of 16s rRNA gene.

为评估核心蛋白聚糖（Biglycan, BGN）缺失对经偶氮甲烷（Azoxymethane, AOM）/葡聚糖硫酸钠（Dextran Sulfate Sodium, DSS）处理的野生型（Wild Type, WT）及BGN(-/0)小鼠肠道菌群的影响，研究人员对粪便样本开展了16S rRNA基因高通量测序。