Transcriptional analysis of islets of Langerhans from organ donors of different ages
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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http://data.iscr.ac.cn/Article?id=d1b0a62330abfbcb5750c5c1f3d231c6
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资源简介：
Islet function diminishes with age and as such the incidence of type 2 diabetes increases. The cause of this is unknown. In this study whole islets were extracted with laser capture microdissection from organ donors 1-81 years of age. Increasing age was associated with a downregulation of pathways associated with the cell cycle and increase in markers of senescence e.g. CDKN2A. Among novel genes increasing with age was SPP1.
提供机构：
Uppsala University
创建时间：
2022-02-20
