Burkholderia_Northeast_Thailand. Burkholderia_Northeast_Thailand

Burkholderia pseudomallei is a soil organism found in many parts of the world. Through direct contact with contaminated soil/water, humans acquire infection and develop melioidosis. The disease, ofiten fatal, display broad clinical manifestations, with different disease patterns being reported. Little is known about factors influencing the disease outcomes and its geographical signatures. We hypothesise that bacterial genetics might contribute to the disease outcomes in that specific factors might have an impact on acquisition, disease manifestations and severity. By combining this newly sequenced collection and the existing collection, we propose to mine the genomes for geneitc factors that potentially facilitate disease development and the specificity factor that influence the patterns of clinical manifestations. Ultimately, a better understanding of bacterial disease-causing factors will aid a control of melioidosis. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/

类鼻疽伯克霍尔德菌（Burkholderia pseudomallei）是一种广泛分布于全球多地的土壤微生物。人类可通过接触受污染的土壤或水源发生感染，进而罹患类鼻疽（melioidosis）。该病常可致命，临床表现谱广泛，已有多种不同疾病分型的报道。目前学界对影响疾病转归及其地理特征的相关因素仍知之甚少。我们提出如下假说：细菌遗传学或可参与调控疾病转归，特定遗传因子可能对感染的获得、临床表现及病情严重程度产生影响。本研究计划整合本次新测序的菌株集合与现有菌株集合，从基因组中挖掘潜在促进疾病发生的遗传因子，以及影响临床表现谱的特异性因子。最终，对细菌致病因子的深入理解将有助于类鼻疽的防控工作。本数据集属于预发布数据。有关威康桑格研究所（Wellcome Trust Sanger Institute）共享的预发布数据的合规使用规范（含各类出版暂缓相关细则），请访问http://www.sanger.ac.uk/datasharing/ 查询详情。