Supporting data for: Disrupted hippocampal replay is associated with reduced offline map stabilisation in an Alzheimer’s mouse model

Data from Shipley et al. Disrupted hippocampal replay is associated with reduced offline map stabilisation in an Alzheimer’s mouse model.
In-vivo single cell electrophysiology data recorded from the pyramidal cell layer of the CA1 region of the hippocampus, from 15 male APP NL-G-F/Chat-Cre mice as they performed a memory task on an 8-arm radial arm maze. Neural data were collected via tetrodes carrying 64 channels (16 tetrodes) microwire electrodes, using the OpenEphys aquisition board.
Data were initially spike sorted using the automatic clustering algorith Kilosort2.0 and then manually refined in Phy. The output from spike sorting is stored in NPY format, including spike times (spike_times.npy), spike cluster allocation (spike_clusters.npy) and general cluster information (cluster_info.npy) for each recording day. trialData_newMUA matlab files provide partially processed information, such as allocation of spikes to different behavioural trials and position data. All data were collected between 2019 and 2022 - specific dates for each recording are provided as folder labels.

Excel files provide details about genotype and task performance. Associated code can be found at github.com/Barry-lab.

本数据集源自Shipley团队的研究《阿尔茨海默病小鼠模型中海马体重播紊乱与离线认知图谱稳定化减弱相关》。
本数据集包含15只雄性APP NL-G-F/Chat-Cre小鼠在八臂放射臂迷宫中完成记忆任务时，采集的海马CA1区锥体细胞层的体内单细胞电生理数据。神经数据通过搭载64通道（16根四极电极）的微丝电极，结合OpenEphys采集板完成采集。
神经锋电位数据首先采用自动聚类算法Kilosort2.0进行锋电位分类，随后在Phy软件中完成手动精修。锋电位分类的结果以NPY格式存储，涵盖各记录日的锋电位时间（spike_times.npy）、锋电位簇分配信息（spike_clusters.npy）以及簇的通用属性信息（cluster_info.npy）。
trialData_newMUA MATLAB文件则提供了部分预处理后的信息，包括锋电位在不同行为试次中的分配情况以及位置追踪数据。所有数据采集于2019年至2022年期间，各记录的具体日期以文件夹标签形式标注。
Excel文件包含小鼠基因型与任务表现的详细信息，配套代码可在github.com/Barry-lab获取。