Intrapartum Nitrous Oxide: Satisfaction, Side Effects, and Predictors of Conversion

In 2015, the Intrapartum Nitrous Oxide Workgroup (I-NOW group) designed a multi-institutional database, Intrapartum Nitrous Oxide Database (I-NOW database), to collect data on births during which N2O was used. The goal of compiling data on N2O use from a variety of U.S. institutions was to evaluate unaddressed aspects of intrapartum N2O use with a focus on safety and best-use practices. This dataset holds data from one institution in the workgroup for 463 intrapartum adult (≥ 18 years old) patients who used nitrous oxide. The data points include demographics, medical history, obstetric history, side effects and satisfaction scores for nitrous oxide, conversion to other methods, and reasons for conversion.
Labor induction, medical augmentation, parity, trial of labor after cesarean delivery (TOLAC), and post-nitrous cervical dilation all had significant effects on the rate of conversion to neuraxial analgesia. Side effects related to inhaled N2O use during labor were rare and were not a significant reason for conversion to neuraxial analgesia. Newborn Apgar scores averaged 8 and 9 at 1 and 5 minutes respectively.

2015年，产时一氧化二氮工作组（Intrapartum Nitrous Oxide Workgroup，I-NOW工作组）搭建了多中心数据库，命名为产时一氧化二氮数据库（Intrapartum Nitrous Oxide Database，I-NOW数据库），用于收录使用一氧化二氮（N₂O）的分娩相关数据。该数据库旨在汇集美国多家医疗机构的一氧化二氮使用数据，以评估产时一氧化二氮应用中尚未被充分研究的方向，重点关注其安全性与最佳临床实践规范。
本数据集收录了该工作组内1家医疗机构的相关数据，涉及463名使用一氧化二氮的产时成年产妇（年龄≥18周岁）。数据字段涵盖人口统计学信息、既往病史、产科病史、一氧化二氮相关不良反应与满意度评分、镇痛方式转换情况及转换原因。
引产、医学催产、产次、剖宫产后阴道试产（Trial of Labor After Cesarean Delivery，TOLAC）以及使用一氧化二氮后的宫颈扩张程度，均对椎管内镇痛转换率存在显著影响。分娩期间吸入一氧化二氮相关的不良反应极为罕见，且并非椎管内镇痛转换的重要诱因。新生儿1分钟与5分钟的Apgar评分均值分别为8分与9分。